5-Hydroxyindole, CAS 1953-54-4

Formulation: A solid

Formal Name: 1H-indol-5-ol

Purity: ≥98%

Formula Markup: C8H7NO

Formula Weight: 133,1

Shelf life (days): 1460

CAS Number: 1953-54-4

Notes: 5-Hydroxyindole is a neuroactive metabolite of L-tryptophan (Item No. 29600).{65129} It is formed from L-tryptophan by gut microbiota expressing tryptophanase (TnaA) via 5-hydroxy-L-tyrptophan (5-HTP; Item No. 20539) and indole intermediates.{65129,65130} 5-Hydroxyindole (0.03-30 mM) potentiates transient inward currents induced by acetylcholine (Item No. 23829) in Xenopus oocytes expressing α7 nicotinic acetylcholine receptors (nAChRs).{65131} It also potentiates ion currents induced by serotonin (5-HT; Item No. 14332) in N1E-115 mouse neuroblastoma cells when used at a concentration of 1 mM.{65132} 5-Hydroxyindole (30 mg/kg) decreases gastrointestinal transit time in rats.{65130} It induces convulsions in rats when administered at doses ranging from 50 to 100 mg/kg.{65133} Serum 5-hydroxyindole levels are positively correlated with working memory in patients with schizophrenia.{65129}

• SKU: CAY36431-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36431-1
• Green Labware: No
• Package Unit: 1 g
• Quantity Unit: STK
• Application: Reinstoffe