5α-Androst-16-en-3α-ol, CAS 1153-51-1

Formulation: A crystalline solid

Formal Name: (3α,5α)-androst-16-en-3-ol

Purity: ≥95%

Formula Markup: C19H30O

Formula Weight: 274,4

Shelf life (days): 1460

CAS Number: 1153-51-1

Notes: 5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.{57543,57544} It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM).{57544} 5α-Androst-16-en-3α-ol (0.1-1 µM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2 and α2β2γ2 subunit-containing GABAA receptors. In vivo, 5α-androst-16-en-3α-ol (5-10 mg/kg) decreases immobility time in the forced swim test in mice. It increases time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at doses ranging from 30 to 50 mg/kg. 5α-Androst-16-en-3α-ol protects against seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or electroshock in mice (ED50s = 48.9 and 21.9 mg/kg, respectively).

• SKU: CAY33457-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33457-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK