5α-Dihydroprogesterone, CAS 566-65-4

Formulation: A solid

Formal Name: (5α)-pregnane-3,20-dione

Purity: ≥95%

Formula Markup: C21H32O2

Formula Weight: 316,5

Shelf life (days): 1460

CAS Number: 566-65-4

Notes: 5α-Dihydroprogesterone (5α-DHP) is a progesterone receptor agonist and metabolite of progesterone (Item No. 15876).{59179} It is formed from progesterone by 5α-reductase.{59180} It induces gene expression mediated by the progesterone receptor (PR) in reporter assays using HepG2 cells expressing equine PR or human PR (EC50s = 14 and 23.1 nM, respectively).{59179} 5α-DHP (0.7 mg/kg) maintains equine pregnancy in the absence of luteal progesterone. It increases proliferation of C4HD murine mammary cells when used at a concentration of 1 µM and induces tumor formation in a C4HD mouse model of tumorigenesis in a dose-dependent manner.{59181} 5α-DHP levels increase locally following spinal cord injury or traumatic brain injury in rats and ischemic brain injury in mice.{59180}

• SKU: CAY31505-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 31505-5
• Green Labware: No
• Package Unit: 5 g
• Quantity Unit: STK