Formulation: A solid
Formal Name: (5β)-pregnane-3,20-dione
Purity: ≥95%
Formula Markup: C21H32O2
Formula Weight: 316,5
Shelf life (days): 1460
CAS Number: 128-23-4
Notes: 5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone (Item No. 15876).{61565,61566} It is formed from progesterone by 5β-reductase.{61566} 5β-DHP inhibits spontaneous contractions in isolated rat uterus when used at a concentration of 10 µg/ml, an effect that can be blocked by the progesterone receptor antagonist RU486 (mifepristone; Item No. 10006317) but not the GABAA receptor antagonist picrotoxin (Item No. 20771).{61565} It is a negative modulator of homooligomeric ρ1 subunit-containing GABAA receptors, inhibiting GABA-induced currents in X. laevis oocytes expressing these receptors (IC50 = 5.02 µM).{61567} Plasma levels of 5β-DHP decrease at the onset of spontaneous human labor.{61568}
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