(±)8(9)-EET

Formulation: A solution in ethanol

Formal Name: (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid

Purity: ≥98%

Formula Markup: C20H32O3

Formula Weight: 320,5

Shelf life (days): 730

Notes: (±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Item No. 90010).{463,729} (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex.{1116} It activates PPARα in HEK293 cells when used at a concentration of 1 µM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion.{42155} It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM.{34481} (8S,9R)-EET (1 µg/kg), but not (8R,9S)-EET, reduces the glomerular filtration rate (GFR) through COX-dependent pre-glomerular vasoconstriction in rats.{1111}

• SKU: CAY50351-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 50351-500
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK