852A, CAS 532959-63-0

Formulation: A solid

Formal Name: N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-methanesulfonamide

Purity: ≥98%

Formula Markup: C17H23N5O2S

Formula Weight: 361,5

Shelf life (days): 1460

CAS Number: 532959-63-0

Notes: 852A is a toll-like receptor 7 (TLR7) agonist.{51490} It selectively induces NF-κB signaling in HEK293 cells expressing recombinant human TLR7 but not HEK293 cells expressing recombinant human TLR8 or TLR9 when used at a concentration of 1 µM. 852A (10-1,000 ng/ml) also induces IFN-α production in plasmacytoid dendritic cell-enriched but not plasmacytoid dendritic cell-depleted isolated human peripheral blood mononuclear cells (PBMCs). In vivo, 852A (150 mg/kg) delays the onset of lung metastasis in a B16/F10 murine melanoma model.{51491}

• SKU: CAY39512-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39512-5
• Package Unit: 5 mg
• Quantity Unit: STK