Formulation: A solid
Formal Name: N-5-isoquinolinyl-N′-[[4-(trifluoromethyl)phenyl]methyl]-urea
Purity: ≥98%
Formula Markup: C18H14F3N3O
Formula Weight: 345,3
Shelf life (days): 1460
CAS Number: 581809-67-8
Notes: A-425619 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{66952} It is selective for TRPV1 over a panel of 83 receptors, enzymes, transporters, and ion channels at 10 µM. A-425619 inhibits increases in intracellular calcium induced by capsaicin (Item No. 92350), N-arachidonoyl dopamine (NADA; Item No. 90057), anandamide (arachidonoyl ethanolamide; Item No. 90050), or acid in HEK293 cells expressing human TRPV1 (IC50s = 5, 4, 3, and 2 nM, respectively). It increases core body temperature in rats when administered at a dose of 30 mg/kg.{66953} A-425619 increases the paw withdrawal threshold in several rodent models of inflammatory, neuropathic, osteoarthritic, and postoperative pain in a dose-dependent manner.{66954}
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