A-867744, CAS 1000279-69-5

Formulation: A crystalline solid

Formal Name: 4-[5-(4-chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]-benzenesulfonamide

Purity: ≥98%

Formula Markup: C20H19ClN2O3S

Formula Weight: 402,9

Shelf life (days): 1460

CAS Number: 1000279-69-5

Notes: A-867744 is a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs).{52986} It is selective for α7 nAChRs over α3β2- or α4β2 subunit-containing nAChRs (IC50s = 0.023, 19.5 and 6.4 µM, respectively) and the serotonin (5-HT) receptor subtype 5-HT3A (Ki = >30 µM). A-867744 potentiates ACh-induced currents in Xenopus oocytes expressing human α7 nAChRs (EC50 = ~1 µM). In vivo, A-867744 (0.1-10 μmol/kg, i.p.) improves sensory gating deficits in a paired auditory stimulus paradigm in mice.{52987}

• SKU: CAY32974-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 32974-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK