α-CGRP (human) (trifluoroacetate salt)

Formulation: A lyophilized powder

Purity: ≥95%

Formula Markup: C163H267N51O49S2 • XCF3COOH

Formula Weight: 3789,3

Shelf life (days): 1460

Notes: α-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with diverse biological activities.{41395} It belongs to the calcitonin family of peptides, which also includes amylin (Item No. 24274), calcitonin (Item Nos. 24409 / 24410), and adrenomedullin.{38633} α-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.1 nM) over a complex of CLCR and RAMP2 (IC50 = 1,300 nM).{41396} It also binds selectively to complexes of human calcitonin receptor 2 (CTR2) and RAMP1 (IC50 = 43.7 nM) compared to CTR2 and RAMP2 complexes (IC50 = 141.3 nM) in amylin radioligand displacement assays.{39433} α-CGRP induces cAMP-activated currents in Xenopus oocytes with endogenous Cgrp receptors that overexpress RAMP1 (EC50 = 9 nM).{41396} It also induces cAMP accumulation in COS-7 cells transfected with both CTR2 and RAMP1 (EC50 = 8.32 nM).{39433}

• SKU: CAY24405-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 24405-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK