Formulation: A solid
Formal Name: cyclic (2→8), (3→15)-bis(disulfide), glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-tyrosyl-L-prolyl-L-prolyl-L-cysteinyl-L-phenylalanyl-L-alanyl-L-threonyl-L-asparaginyl-L-prolyl-L-α-aspartyl-L-cysteinamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C65H89N17O21S4 • XCF3COOH
Formula Weight: 1572,8
Shelf life (days): 1460
Notes: α-Conotoxin AuIB is a conotoxin that has been found in C. aulicus and has receptor antagonist and analgesic activity.{61522} It is a peptide antagonist of α3β4 subunit-containing nicotinic acetylcholine receptors (nAChRs; IC50 = 0.75 µM). It is greater than 100-fold selective for α3β4 subunit-containing nAChRs over those containing α2β2, α2β4, α3β2, α4β2, α4β4, or α1β1γδ subunits but does inhibit homomeric α7 nAChRs by 34% at 3 µM. Intrathecal administration of α-conotoxin AuIB (0.2 and 2 nmol/animal) reduces mechanical allodynia in a rat model of neuropathic pain induced by partial sciatic nerve ligation.{61523} It also reverses somatic signs of withdrawal in a mouse model of morphine withdrawal when administered intracerebroventricularly at doses of 1.75 and 3.5 pmol/animal.{61524}
English
Deutsch
