Formulation: A solid
Formal Name: 3-(2-aminopropyl)-1H-indol-5-ol, (2Z)-2-butenedioate
Purity: ≥98%
Formula Markup: C11H14N2O • C4H4O4
Formula Weight: 306,3
Shelf life (days): 1460
CAS Number: 97469-12-0
Notes: α-methyl Serotonin is an agonist of serotonin (5-HT) receptors.{47638,47647} It binds selectively to 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D receptors over 5-HT1E receptors (Kis = 42, 85, 150, 150, and >10,000 nM, respectively).{47638} It is also selective for 5-HT2B and 5-HT2C receptors over 5-HT2A receptors (EC50s = 2.98, 50.1, and 794 nM, respectively).{47647} α-methyl Serotonin (30 μM) potentiates motor neuron depolarizations induced by NMDA (Item No. 14581) in the presence of the NMDA receptor antagonist memantine (Item No. 14184) in R. pipiens (frog) spinal cord ex vivo.{47648} It also increases dopamine release from rat striatum in vivo in a dose-dependent manner.{47649} α-methyl Serotonin (64 μg/kg) increases systolic blood pressure and transiently increases heart rate in conscious dogs.{47650}
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