α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt), CAS 171869-93-5

Formulation: A solid

Purity: ≥98%

Formula Markup: C77H109N21O19S • XCF3COOH

Formula Weight: 1664,9

Shelf life (days): 1460

CAS Number: 171869-93-5

Notes: α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.{47500} It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).{45139} α-MSH (100 pM) reduces S. aureus colony formation and C. albicans germ tube formation in vitro.{55058} It inhibits endotoxin-, ceramide-, TNF-α-, or okadaic acid-induced activation of NF-κB in U937 cells.{47500} α-MSH reduces IL-6- or TNF-α-induced ear edema in mice.{55059} It also prevents the development of adjuvant-induced arthritis in rats and increases survival in a mouse model of septic shock. Increased plasma levels of α-MSH are positively correlated with delayed disease progression and reduced death in patients with HIV.{47500}

• SKU: CAY29923-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29923-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK