Formulation: A solid
Formal Name: N-acetyl-α-L-aspartyl-L-glutamic acid
Purity: ≥95%
Formula Markup: C11H16N2O8
Formula Weight: 304,3
Shelf life (days): 1460
CAS Number: 3106-85-2
Notes: α-NAAG is a peptide neurotransmitter that is widely expressed throughout mammalian central and peripheral nervous systems.{58431} Following synaptic release, α-NAAG activates postsynaptic metabotropic glutamate receptor 3 (mGluR3) to inhibit cAMP production in neurons and astrocytes, as well as acts on presynaptic mGluR3 to inhibit the release of amine neurotransmitters, including GABA and glutamate.{58431,58432} Increasing α-NAAG levels via NAAG peptidase inhibition reduces trauma-induced excitotoxic cell death in a mouse model of traumatic brain injury, as well as reduces hyperalgesia in various rodent pain models and schizophrenia-like stereotypic behaviors induced by phencyclidine in rats.{58431} Tumor levels of α-NAAG are positively correlated with tumor grade in patients with gliomas and meningiomas.{58433}
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