Formulation: A liquid
Formal Name: (1S,4R,5R)-4-methyl-1-(1-methylethyl)-bicyclo[3.1.0]hexan-3-one
Purity: ≥95%
Formula Markup: C10H16O
Formula Weight: 152,2
Shelf life (days): 1460
CAS Number: 546-80-5
Notes: (–)-α-Thujone is a monoterpene ketone and a major component of absinthe and has diverse biological activities.{67513,67512,67514,67515} It inhibits currents induced by acetylcholine (ACh) in Xenopus oocytes expressing human α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 27 µM).{67513} (–)-α-Thujone (100 and 300 µM) reduces GABA-induced current amplitude in HEK293 cells expressing α1β2δ subunit-containing GABA receptors.{67512} It reduces levels of the Norovirus surrogates feline calcivirus-F9 (FCV-F9) and murine norovirus 1 (MNV-1) in a plaque formation assay when used at a concentration of 25 mM.{67514} In vivo, (–)-α-thujone (1.25 mg/kg, i.p.) impairs nicotine-induced enhancement of long-term potentiation in the dentate gyrus, a marker of learning and memory, in rats.{67513} It also inhibits lung metastasis and increases survival in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg.{67515}
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