AA43279, CAS 354812-16-1

Formulation: A solid

Formal Name: 3-amino-5-(4-methoxyphenyl)-2-thiophenecarboxamide

Purity: ≥98%

Formula Markup: C12H12N2O2S

Formula Weight: 248,3

Shelf life (days): 1460

CAS Number: 354812-16-1

Notes: AA43279 is an activator of voltage-gated sodium channel 1.1 (Nav1.1; EC50 = 9.5 µM in a patch-clamp assay using HEK293 cells expressing the human channel).{66683} It is selective for Nav1.1 over Nav1.4 and Nav1.7 at 30 µM but also activates Nav1.2, Nav1.5, and Nav1.6 (EC50s = 22.8, 14.4, and 11.6 µM, respectively). AA43279 also inhibits IκB kinase β (IKKβ; IC50 = 2.9 µM).{66684} It increases the seizure threshold in the maximal electroshock seizure threshold (MEST) test in mice when administered at a dose of 300 mg/kg.{66683}

• SKU: CAY40428-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40428-5
• Package Unit: 5 mg
• Quantity Unit: STK