AAA

Formulation: A crystalline solid

Formal Name: (20-hydroxyicosa-6Z,15Z-dienoyl)aspartate, disodium salt

Purity: ≥98%

Formula Markup: C24H39NO6 • 2Na

Formula Weight: 483,5

Shelf life (days): 730

Notes: AAA is an antagonist of G protein-coupled receptor 75 (GPR75).{58283} It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 µM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells. In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension when administered prior to induction or after establishment of hypertension.{58282}

• SKU: CAY32733-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 32733-500
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK