Formulation: A solid
Formal Name: 3-[2-(6-methyl-2-pyridinyl)ethynyl]-2-cyclohexen-1-one, O-methyloxime
Purity: ≥98%
Formula Markup: C15H16N2O
Formula Weight: 240,3
Shelf life (days): 1460
CAS Number: 924298-51-1
Notes: ABP 688 is a non-competitive antagonist of metabotropic glutamate receptor 5 (mGluR5; Ki = 3.5 nM in a radioligand binding assay using L(tk-) cell membranes expressing human receptors).{53878} It is selective for mGluR5 receptors over a panel of CNS G protein-coupled receptors, ion channels, and transporters at 10 μM. ABP 688 inhibits quisqualate-induced phosphoinositol accumulation in and glutamate-induced calcium release from L(tk-) cells expressing human mGluR5 (IC50s = 2.4 and 2.3 nM, respectively). Radiolabeled forms of ABP 688 have been used as PET tracers for in vivo imaging of mGluR5 receptors in rodents.{53878,53879}
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