Formulation: A solid
Formal Name: 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]-phenol
Purity: ≥98%
Formula Markup: C18H17F3O
Formula Weight: 306,3
Shelf life (days): 1460
CAS Number: 1421854-16-1
Notes: AC-186 is a non-steroidal estrogen receptor β (ERβ) agonist (EC50 = 6 nM in a functional assay).{60459} It is selective for ERβ over ERα (EC50 = 5,000 nM). AC-186 (10 mg/kg) reduces dopaminergic neuronal loss in the substantia nigra, improves novel object recognition, and improves motor performance in male, but not female, rats in a model of Parkinson’s disease induced by 6-OHDA (Item No. 25330). It reduces tactile allodynia in male, but not female or female ovariectomized, rats in a model of spinal nerve ligation-induced neuropathic pain.{60460} AC-186 (10 and 30 mg/kg) also reduces tactile allodynia in male rats in a model of neuropathic pain induced by paclitaxel (Item No. 10461).
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