Formulation: A solid
Formal Name: N-acetyl-30-L-asparagine-32-L-tyrosinamide-8-32-calcitonin (salmon reduced), trifluoroacetate salt
Purity: ≥95%
Formula Markup: C127H205N37O40 • XCF3COOH
Formula Weight: 2890,2
Shelf life (days): 1460
Notes: AC 187 is a synthetic peptide that corresponds to amino acids 8-32 of salmon calcitonin (sCT; Item No. 24410) and an antagonist of calcitonin and amylin receptors.{38808} It inhibits human calcitonin-induced cAMP accumulation in COS-7 cells expressing the human calcitonin receptor or the human amylin receptors AMY1a or AMY3a (pKBs = 7.15, 7.3, and 7.37, respectively). AC 187 (10 µM) protects against apoptosis induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat basal forebrain neurons.{68410} Intrathecal administration of AC 187 (50 µl of a 3 µg/µl solution) increases the paw withdrawal threshold in the von Frey test in a rat model of chronic peripheral neuropathic pain induced by spared nerve injury.{68411} AC 187 (10 µg/kg) reverses sCT-induced decreases in food intake in food-deprived rats.{68412}
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