Formulation: A solid
Formal Name: 3-(acetyl-2,2,2-d3-amino)-1-propanesulfonic acid, hemicalcium salt (2:1)
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C5H7D3NO4S • 1/2Ca
Formula Weight: 203,3
Shelf life (days): 1460
CAS Number: 1225580-94-8
Notes: Acamprosate-d3 is intended for use as an internal standard for the quantification of acamprosate (Item No. 23899) by GC- or LC-MS. Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; Item No. 20701).{36372} Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 µM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release.{36373,36371,36374} It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors.{36374} Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline (Item No. 11727). Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.
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