Formulation: A solid
Formal Name: 4,5-dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
Purity: ≥98%
Formula Markup: C12H10O4
Formula Weight: 218,2
Shelf life (days): 1460
CAS Number: 72420-38-3
Notes: Acifran is a niacin receptor agonist.{63138,63139} It binds to hydroxycarboxylic acid receptor 2 (HCA2), known previously as G protein-coupled receptor 109A (GPR109A) and niacin receptor 1, with an IC50 value of 1.12 µM, as well as induces ERK1/2 phosphorylation in CHO-K1 cells expressing HCA2 or HCA3, also known as GPR109B and niacin receptor 2 , when used at concentrations ranging from 0.01 to 10 µM. Acifran (1 mg/kg) reduces serum triglyceride and LDL levels and increases the ratio of HDL to total cholesterol in hyperlipidemic rats.{63140} It also reduces serum triglyceride levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).
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