Formulation: A solid
Formal Name: 2-chloro-4-[(3-endo)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]oct-8-yl]-3-methyl-benzonitrile
Purity: ≥95%
Formula Markup: C16H19ClN2O
Formula Weight: 290,8
Shelf life (days): 1460
CAS Number: 899821-23-9
Notes: ACP-105 is a non-steroidal androgen receptor (AR) agonist.{68810} It increases proliferation in a receptor selection and amplification technology (R-SAT) assay using NIH3T3 cells expressing AR or AR containing a tyrosine-to-alanine substitution at position 877 (ART887A; EC50s = 1 and 0.4 nM, respectively). ACP-105 (1 mg/kg per day) inhibits radiation-induced decreases in contextual fear conditioning freezing time, indicating a reversal of memory deficits, in female mice.{68811} It reduces the frequency of time spent in the external and intermediate zone in an open field test, indicating anxiolytic-like activity, in combination with the non-steroidal estrogen receptor β (ERβ) agonist AC-186 (Item No. 33526) in a gonadectomized 3xTg mouse model of Alzheimer's disease when administered at a dose of 10 mg/kg per day for four months.{68812} ACP-105 (10 mg/kg per day for seven months), in combination with AC-186, decreases amyloid-β (1-40) (Aβ40) and Aβ42 levels in the brains, as well as increases the levels of ARs and the amyloid-β degrading enzymes neprilysin and insulin-degrading enzyme in the hippocampus, of gonadectomized 3xTg mice.
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