ACT-709478, CAS 1838651-58-3

Formulation: A solid

Formal Name: N-[1-[(5-cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]-benzeneacetamide

Purity: ≥98%

Formula Markup: C22H18F3N5O

Formula Weight: 425,4

Shelf life (days): 1460

CAS Number: 1838651-58-3

Notes: ACT-709478 is an inhibitor of T-type voltage-gated calcium channel 3.1 (Cav3.1), Cav3.2, and Cav3.3 (IC50s = 6.4, 18, and 7.5 nM, respectively).{40561} It is selective for T-type calcium channels over the L-type calcium channel Cav1.2 (IC50 = 2,410 nM). ACT-701478 (10 mg/kg) reduces the cumulative duration of absence-like seizures in rats. It also reduces the severity of seizures in a rat model of audiogenic seizures when administered at a dose of 100 mg/kg.

• SKU: CAY25371-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 25371-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK