Formulation: A solid
Formal Name: L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycine, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C59H78N16O16S • XCF3COOH
Formula Weight: 1299,4
Shelf life (days): 1460
Notes: Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.{49033,45140} The amino acid sequence of ACTH (1-10) is common to ACTH and α-melanocyte stimulating hormone.{45139} ACTH (1-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 2.6 and 200 nM, respectively, for the recombinant human receptors) and increases adenylate cyclase activity in HEK293 cells expressing human recombinant MC1R (EC50 = 25 nM).{45139,49034} It inhibits extinction of the conditioned avoidance response rats in shuttle-box and pole-jumping tests when administered at doses of 10 and greater than 20 μg, respectively.{49033,49035} Intracerebroventricular injection of ACTH (1-10) reduces the incidence and severity of cold-restraint stress-induced gastric lesions in rats.{49036}
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