Formulation: A solid
Formal Name: 6-(3-((3R,5R,7R)-adamantan-1-yl)-4-(methoxy-d3)phenyl)-2-naphthoic acid
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C28H25D3O3
Formula Weight: 415,5
Shelf life (days): 1460
CAS Number: 1276433-89-6
Notes: Adapalene-d3 is intended for use as an internal standard for the quantification of adapalene (Item No. 13655) by GC- or LC-MS. Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively).{18516,37761,37762,37763,37764} It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).{37761} It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.{37762} It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.{37761} Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.{37764,37763} Formulations containing adapalene have been used in the treatment of acne vulgaris.
English
Deutsch
