Formulation: A crystalline solid
Formal Name: α-phenyl-benzeneacetic acid, 2-(diethylamino)ethyl ester, monohydrochloride
Purity: ≥98%
Formula Markup: C20H25NO2 • HCl
Formula Weight: 347,9
Shelf life (days): 1460
CAS Number: 50-42-0
Notes: Adiphenine is an anticholinergic agent.{52813,52814,52815,52816} It is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50s = 1.8, 3.7, and 6.3 µM for the α3β4, α4β2, and α4β4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM).{52813,52814} Adiphenine inhibits contractions induced by acetylcholine (ACh) in isolated guinea pig ileum in a concentration-dependent manner.{52814} It prevents tonic hindlimb extension in a mouse model of seizures induced by maximal electroshock (MES) with an ED50 value of 62 mg/kg but is neurotoxic at higher doses.{52815} Adiphenine protects against organophosphate-induced lethality in mice with a 50% protective dose (PD50) value of 3.3 mg/kg.{52816} It has also been used as a local anesthetic.{52813,52815}
English
Deutsch
