ADL 08-0011 (hydrochloride), CAS 170098-43-8

Formulation: A solid

Formal Name: [3R-[1(S*),3α,4α]]-4-(3-hydroxyphenyl)-3,4-dimethyl-α-(phenylmethyl)-1-piperidinepropanoic acid, monohydrochloride

Purity: ≥90%

Formula Markup: C23H29NO3 • HCl

Formula Weight: 403,9

Shelf life (days): 1460

CAS Number: 170098-43-8

Notes: ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan (Item No. 23902).{41514} It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.{58567}

• SKU: CAY34298-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34298-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK