Formulation: A solid
Formal Name: L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valinamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C44H69N15O9 • XCF3COOH
Formula Weight: 952,1
Shelf life (days): 1460
Notes: Adrenorphin is an octapeptide agonist of μ-opioid receptors that is involved in nociception.{51269,51270} It is a C-terminally amidated cleavage product corresponding to amino acids 210-218 of human proenkephalin A. It was originally found in a human pheochromocytoma but has also been found in the rat adrenal medulla and the rat olfactory bulb, hypothalamus, and striatum, among other brain regions.{51269,51271,51272} Adrenorphin selectively binds to μ-opioid receptors over κ- and δ-opioid receptors (Kis = 0.12, 0.248, and 2.65 nM, respectively, in a radioligand binding assay).{51269} Intracerebroventricular administration of adrenorphin (6.1 nmol/animal) increases the latency to paw licking in the hot plate test in mice, indicating analgesic activity, an effect that can be reduced by the non-selective opioid receptor antagonist naloxone.{51270} It also induces respiratory depression in mice and rabbits (ED50s = 6 and 71.1 nmol/animal, respectively).
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