Formulation: A crystalline solid
Formal Name: (2S,3E,7aS,12aS,12bS,15R)-3-ethylidene-1,3,4,6,7,12b-hexahydro-9-hydroxy-12-methyl-2H,12H-12a,2,7a-(epoxyethanylylidene)indolo[2,3-a]quinolizine-15-carboxylic acid, methyl ester
Purity: ≥98%
Formula Markup: C22H26N2O4
Formula Weight: 382,5
Shelf life (days): 730
CAS Number: 3512-87-6
Notes: Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity.{63382} It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis = 0.3, 1.68, and 10.4 µM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s = 2.6 and 0.073 µM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
English
Deutsch
