Formulation: A solid
Formal Name: L-alanyl-L-seryl-L-alanyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C109H163N25O32S • XCF3COOH
Formula Weight: 2367,7
Shelf life (days): 1460
Notes: [Ala1,3,11,15]-Endothelin-1 is an endothelin receptor type B (ETB) agonist and linear synthetic peptide derivative of endothelin-1 in which all four cysteine residues have been substituted with alanine.{51666} It selectively binds to ETB over ETA receptors (IC50s = 0.33 and 570 nM, respectively, for the porcine receptors). [Ala1,3,11,15]-Endothelin-1 (10 and 100 nM) increases wound closure percentage in a scratch assay using human umbilical vein endothelial cells (HUVECs).{51667} It increases body temperature in conscious rabbits when administered at doses of 0.15 or 0.3 nmol/kg.{51668} [Ala1,3,11,15]-Endothelin-1 (20 nmol/kg, i.v.) induces bronchoconstriction and increases mean arterial blood pressure in anesthetized guinea pigs.{51669} It has been used to determine the cross reactivity of monoclonal antibodies against endothelin in enzyme immunometric assays.{1338}
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