Formulation: A solid
Formal Name: 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide
Purity: ≥95%
Formula Markup: C21H23Cl2N3O
Formula Weight: 404,3
Shelf life (days): 1460
CAS Number: 82626-01-5
Notes: Alpidem is an anxiolytic agent.{58519} It selectively binds to α1β2γ2 subunit-containing GABAA receptors over α5β2γ2 subunit-containing GABAA receptors in HEK293 cells (IC50s = 0.017 and ≥10 µM, respectively, for the recombinant rat receptors).{58520} Alpidem also binds to the GABAA/benzodiazepine receptor complex and translocator protein 18 kDa (TSPO) with IC50 values of 0.028 and 0.0079 µM, respectively.{58521} It reduces marble burying in mice, indicating anxiolytic activity, with a minimum effective dose (MED) of 10 mg/kg.{58522} Unlike the benzodiazepine alprazolam, alpidem does not induce sedation in mice when administered at doses up to 2 mg/kg.{58523} Formulations containing alpidem have previously been used in the treatment of generalized anxiety disorder.
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