Formulation: A solid
Formal Name: trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol-d5, monohydrochloride
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C13H13Br2D5N2O • HCl
Formula Weight: 419,6
Shelf life (days): 1460
CAS Number: 2741380-71-0
Notes: Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol (Item No. 19377) by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine.{60276} It inhibits the voltage-gated sodium channel Nav1.2 in isolated dorsal root neurons (IC50 = 110 µM for the rat channel).{64994} Ambroxol decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM).{36407} It decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells when used at a concentration of 100 µM and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells.{33409} Ambroxol (30, 60, or 120 mg/kg) increases phenol red secretion, a marker of expectorant activity, in mice.{60277} Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions.
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