AMG 333, CAS 1416799-28-4

Formulation: A solid

Formal Name: 6-[[[(S)-(3-fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid

Purity: ≥98%

Formula Markup: C20H12F5N3O4

Formula Weight: 453,3

Shelf life (days): 1460

CAS Number: 1416799-28-4

Notes: AMG 333 is an antagonist of transient receptor potential melastatin 8 (TRPM8; IC50s = 13 and 20 for the human and rat channels, respectively).{69085} It is selective for TRPM8 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, and TRP ankyrin 1 (TRPA1; IC50s = >20, >20, >20, and >40 µM, respectively), as well as a panel of 100 kinases and 144 additional targets at 1 and 10 µM, respectively. AMG 333 (0.6-3 mg/kg) decreases wet-dog shakes, a behavioral marker of cold sensation, induced by the TRPM8 agonist icilin (Item No. 10137) in rats.

• SKU: CAY36825-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36825-25
• Package Unit: 25 mg
• Quantity Unit: STK
• Application: Reinstoffe