AMG 517, CAS 659730-32-2

Formulation: A crystalline solid

Formal Name: N-[4-[[6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]-acetamide

Purity: ≥98%

Formula Markup: C20H13F3N4O2S

Formula Weight: 430,4

Shelf life (days): 1460

CAS Number: 659730-32-2

Notes: AMG 517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1; IC50 = 0.9 nM).{45105} It inhibits mechanical and thermal allodynia in a rat model of burn injury when administered intrathecally at a dose of 165 µg.{35412} AMG 517 (150 and 300 µg/kg) also reverses increases in the level of calcitonin gene-related peptide (CGRP) and increases expression of GFAP and GAP-43 in the dorsal horn of the spinal cord, as well as enhances axonal regeneration in a rat model of sciatic nerve transection injury.{45106}

• SKU: CAY26191-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26191-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK