AMX12006, CAS 2639775-01-0

Formulation: A solid

Formal Name: 4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]-benzoic acid

Purity: ≥98%

Formula Markup: C26H22F3N3O3

Formula Weight: 481,5

Shelf life (days): 1095

CAS Number: 2639775-01-0

Notes: AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM).{65811} It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces tumor volume alone or in combination with the 5-fluorouracil prodrug capecitabine (Item No. 10487) in CT26 murine colon cancer models when administered at a dose of 150 mg/kg.

• SKU: CAY39027-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39027-1
• Package Unit: 1 mg
• Quantity Unit: STK