Formulation: A lyophilized powder
Formal Name: cyclic (2→7)-disulfide, L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosinamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C165H261N51O55S2 • XCF3COOH
Formula Weight: 3903,3
Shelf life (days): 1460
Notes: Amylin is a peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.{35231} Native amylin is a cleavage product of proamylin that is processed and amidated at the C-terminus, a modification that is required for its biological activities.{41794} Amidated amylin increases the rate of glycogen synthesis induced by insulin in isolated rat soleus muscle when used at a concentration of 1 nM, while linear non-amidated amylin has no effect. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes and, in vitro, amidated amylin is more amyloidogenic than the free acid form.{35232,41795} Amylin (human) (amidated) is a 37-residue amidated form of amylin that contains a disulfide bridge between cysteines two and seven.
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