Formulation: A powder
Formal Name: L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosine, cyclic (2→7)-disulfide, trifluoroacetate
Purity: ≥95%
Formula Markup: C165H260N50O56S2 • XCF3COOH
Formula Weight: 3904,3
Shelf life (days): 1460
Notes: Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.{35231} It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively.{35235} Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes.{35232} Amylin forms fibrils that react to thioflavin T and are organized in a cross-β arrangement of β-strands similar to amyloid-β (1-40) (Aβ40; Item No. 21617) and amyloid-β (1-42) (Aβ42; Item No. 20574) fibrils.{35233},{35234} Aggregated amylin (60 μM) decreases the viability of primary pancreatic islet cell cultures by 60%. It also inhibits electrically-stimulated contractions of guinea pig vas deferens (EC50 = 213 nM).{35236}
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