Formulation: A solid
Formal Name: L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C49H71N13O10 • XCF3COOH
Formula Weight: 1002,2
Shelf life (days): 1460
Notes: Angiotensin A is an angiotensin II type 1 (AT1) and AT2 receptor agonist and active metabolite of the peptide hormone angiotensin II (Item No. 17150).{69091} It is formed from angiotensin II via decarboxylation of the N-terminal aspartate residue. Angiotensin A binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays) and induces calcium mobilization in vascular smooth muscle cells (VSMCs; EC50 = 100 nM). It increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by the AT1 antagonist EXP-3174 (losartan carboxylic acid; Item No. 15957). The ratio of angiotensin A to angiotensin II (Ang A/Ang II) in the plasma is increased in patients with end-stage renal failure and serum levels of angiotensin A are decreased in patients with pulmonary arterial hypertension.{69091,69092}
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