Ani 9, CAS 356102-14-2

Formulation: A solid

Formal Name: 2-(4-chloro-2-methylphenoxy)-acetic acid, 2-[(2-methoxyphenyl)methylene]hydrazide

Purity: ≥98%

Formula Markup: C17H17ClN2O3

Formula Weight: 332,8

Shelf life (days): 730

CAS Number: 356102-14-2

Notes: Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM).{53185} It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.

• SKU: CAY29733-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29733-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK