Formulation: A solid
Formal Name: D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-methionyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-α-glutamyl-L-lysyl-L-glutaminyl-L-α-glutamyl-L-lysyl-L-α-glutamyl-L-lysyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-alanyl-L-asparaginyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-aspartyl-L-threonyl-L-isoleucinamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C161H274N48O46S • XCF3COOH
Formula Weight: 3650,3
Shelf life (days): 1460
Notes: Antisauvagine-30 is a peptide antagonist of corticotropin-releasing factor receptor 2 (CRF2).{64043,64044} It is selective for CRF2α over CRF1 (Kis = 1.75 and 915 nM, respectively for the human receptors).{64043} Antisauvagine-30 (10 nM) inhibits sauvagine-induced cAMP production in HEK293 cells expressing mouse CRF2β.{64044} It prevents stress-induced contextual fear conditioning in mice.{64045} Antisauvagine-30 reduces vasoactive intestinal peptide-induced decreases in food intake in rats.{64046}
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