Formulation: A solid
Formal Name: N-[4-(4-fluorophenyl)-3,4-dihydro-2,2-dimethyl-3-oxo-2H-1,4-benzoxazin-7-yl]-methanesulfonamide
Purity: ≥95%
Formula Markup: C17H17FN2O4S
Formula Weight: 364,4
Shelf life (days): 1460
CAS Number: 945966-46-1
Notes: Apararenone is a non-steroidal mineralocorticoid receptor antagonist (Ki = 0.104 µM for the human receptor).{72554} It is selective for mineralocorticoid receptors over estrogen receptor α (ERα) and ERβ and glucocorticoid, progesterone, and androgen receptors (IC50s = >100 µM for all). Apararenone increases the urinary ratio of sodium to potassium in adrenalectomized rats in a dose-dependent manner. It inhibits aldosterone- and nephrectomy-induced increases in systolic blood pressure and urinary albumin levels, as well as myocardial necrosis and fibrosis, cardiac arterial degeneration, and renal tubule damage, in a rat model of renal hypertension when administered at doses of 3 or 10 mg/kg per day.
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