AR-7, CAS 80306-38-3

Formulation: A crystalline solid

Formal Name: 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine

Purity: ≥98%

Formula Markup: C15H12ClNO

Formula Weight: 257,7

Shelf life (days): 1460

CAS Number: 80306-38-3

Notes: AR-7 is a retinoic acid receptor α (RARα) antagonist.{45302} In mouse fibroblasts, AR-7 (20 μM) increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability. AR-7 is also selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively).{45303}

• SKU: CAY22946-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22946-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK