AR231453, CAS 733750-99-7

Formulation: A solid

Formal Name: N-[2-fluoro-4-(methylsulfonyl)phenyl]-6-[4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-5-nitro-4-pyrimidinamine

Purity: ≥95%

Formula Markup: C21H24FN7O5S

Formula Weight: 505,5

Shelf life (days): 730

CAS Number: 733750-99-7

Notes: AR231453 is an agonist of GPR119.{15794} It increases cAMP accumulation in HIT-T15 β cells that endogenously express high levels of GPR119 (EC50 = 4.7 nM). AR231453 increases insulin release from HIT-T15 cells (EC50 = 3.5 nM) and increases glucose-induced insulin release in isolated rat and mouse islets. It reduces plasma glucose levels in wild-type, KK/Ay, and db/db diabetic mice when administered at a dose of 20 mg/kg.

• SKU: CAY34898-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34898-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK