Formulation: A solid
Formal Name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-yridinedicarboxylic acid, 3-methyl 5-(2-oxopropyl) ester
Purity: ≥98%
Formula Markup: C19H20N2O7
Formula Weight: 388,4
Shelf life (days): 1460
CAS Number: 86780-90-7
Notes: Aranidipine is an antagonist of voltage-gated calcium channel Cav3.2.{39643} It inhibits inward currents in Xenopus oocytes expressing human Cav3.2 channels when used at a concentration of 10 µM. Aranidipine (10 mg/kg) decreases mean blood pressure and increases heart rate in spontaneously hypertensive rats (SHRs).{69819} It increases aortic and coronary blood flow and decreases blood pressure, but not heart rate, in normotensive dogs when administered at a dose of 0.3 mg/kg. Aranidipine (10 µg/kg) decreases blood pressure, as well as increases coronary blood flow velocity and heart contractile force, in dogs.{69820} It inhibits diet-induced increases in serum levels of total cholesterol, phospholipids, and triglycerides, as well as reduces aortic plaque area, in rabbits fed a high-cholesterol diet when administered at doses of 3 or 10 mg/kg. Formulations containing aranidipine have been used in the treatment of hypertension.
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