Formulation: A solid
Formal Name: 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, 2-propyn-1-yl ester, monohydrobromide
Purity: ≥95%
Formula Markup: C10H13NO2 • HBr
Formula Weight: 260,1
Shelf life (days): 1460
CAS Number: 116511-28-5
Notes: Arecaidine propargyl ester is an agonist of M2 muscarinic acetylcholine receptors (mAChRs).{62369} It selectively binds to M2 over M1, M3, M4, and M5 mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 µM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2 = 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 µM.{62370} Arecaidine propargyl ester decreases mean arterial blood pressure in normotensive cats (ED25 = 1.9 nmol/kg).{62371}
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