Formulation: A solid
Formal Name: 3-[4-hydroxy-3,5-bis(3-methyl-2-buten-1-yl)phenyl]-2-propenoic acid
Purity: ≥95%
Formula Markup: C19H24O3
CAS Number: 72944-19-5
Notes: Artepillin C is a prenylated cinnamic acid that has been found in B. grisebachii and has diverse biological activities.{51630,51631,51632,46691,51633,51634} It selectively inhibits aldo-keto reductase 1C3 (AKR1C3; IC50 = 1 µM), also known as prostaglandin F synthase, over AKR1C1, AKR1C2, and AKR1C4 at 100 µM.{51630} It also inhibits lipid peroxidation in isolated human erythrocytes.{51631} Artepillin C (10 µM) induces calcium influx in HEK293T cells expressing human transient receptor potential ankyrin 1 (TRPA1), an effect that can be blocked by the TRPA1 inhibitor HC-030031 (Item No. 11923).{51632} It is cytotoxic to HT-1080 fibrosarcoma and 26-L5 colon cancer cells (IC50s = 45.47 and 59.32 µg/ml, respectively).{46691} Artepillin C is active against C. albicans, E. floccosum, T. rubrum, methicillin-sensitive S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 250, 50, 125, 250, and 250 µg/ml, respectively).{51633} In vivo, artepillin C (1 and 10 mg/kg) decreases carrageenan-induced peritoneal leukocyte infiltration in mice.{51634}
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