Formulation: A solid
Formal Name: 6,7-dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-1(2H)-isoquinolinone
Purity: ≥98%
Formula Markup: C25H25N3O5
Formula Weight: 447,5
Shelf life (days): 1460
CAS Number: 2148339-28-8
Notes: AS-2717638 is a lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50 = 0.038 µM).{69172} It is selective for LPA5 over LPA1, LPA2, and LPA3 (IC50s = >10 µM for all) but also binds to adenosine A1 and μ-opioid receptors at 10 µM. It induces analgesia in a rat model of allodynia induced by LPA or geranylgeranyl pyrophosphate (GGPP; Item No. 63330) when administered at doses of 3, 10, and 30 mg/kg. AS-2717638 (10 and 30 mg/kg) inhibits allodynia induced by prostaglandin E2 (PGE2; Item No. 14010), PGF2α, or AMPA in rats. It increases the paw withdrawal threshold and latency in the von Frey hair and plantar tests, respectively, in rats when administered at a dose of 10 mg/kg.
English
Deutsch
