Formulation: A solid
Formal Name: N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-carbamic acid, butyl ester
Purity: ≥98%
Formula Markup: C23H29N3O4S2
Formula Weight: 475,6
Shelf life (days): 1460
CAS Number: 477775-14-7
Notes: AT2 agonist C21 is an agonist of the angiotensin II type 2 (AT2) receptor.{58396} It selectively binds to the AT2 receptor over the AT1 receptor (Kis = 0.4 and >10 µM, respectively). AT2 agonist C21 (0.1 µM) induces neurite outgrowth in NG 108-15 cells. It reduces mean arterial blood pressure in anaesthetized spontaneously hypertensive rats (SHRs) when administered at a dose of 0.05 mg/kg. AT2 agonist C21 (0.03 mg/kg) reduces right ventricle hypertrophy and fibrosis, as well as lung interstitial and perivascular fibrosis, in a rat model of pulmonary hypertension induced by monocrotaline (MCT; Item No. 16666).{58397} It increases survival and reduces neurological deficits in a mouse model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at the same dose.{58398}
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