Formulation: A solid
Formal Name: 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole
Purity: ≥98%
Formula Markup: C14H16N2
Formula Weight: 212,3
Shelf life (days): 1460
CAS Number: 104054-27-5
Notes: Atipamezole is an antagonist of α2A-adrenergic receptors (α2A-ARs; Ki = 1.86 nM).{25705,25706} It is selective for α2A-ARs over α2B- and α1-ARs (Kis = 1,949.83 and 13,300 nM, respectively), as well as over 40 receptors, ion channels, and transporters (IC50s = 540->10,000 nM). Atipamezole (0.04, 0.08, and 1.2 mg/kg) reverses bradycardia and sedation induced by the α2-AR agonist medetomidine in dogs.{60727} It also prevents hypoalgesia induced by the non-steroidal anti-inflammatory drug (NSAID) ketoprofen in sheep.{60728} Atipamezole (0.3 mg/kg) enhances contralateral circling behavior induced by apomorphine or L-DOPA (Item No. 13248) and prolongs the duration of action of L-DOPA in a rat model of Parkinson’s disease.{25704} Formulations containing atipamezole have been used to reverse the sedative and analgesic effects of dexmedetomidine or medetomidine in dogs.
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