Formulation: A crystalline solid
Formal Name: 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-aspartamide, monotrifluoroacetate salt
Purity: ≥95%
Formula Markup: C23H35N9O8S • CF3COOH
Formula Weight: 711,7
Shelf life (days): 1460
CAS Number: 904763-27-5
Notes: ATN-161 is a peptide derived from fibronectin and an integrin αVβ3 and αVβ5 antagonist.{65023} It binds to αVβ3 and αVβ5 receptors (Kds = 0.69 and 1 µM, respectively) in MDA-MB-231 breast cancer cells, as well as inhibits the interaction between αVβ5 and human angiotensin-converting enzyme 2 (ACE2) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein in a concentration-dependent manner in cell-free assays.{65023,65024} ATN-161 reduces viral titers in Vero E6 cells infected with SARS-CoV-2 (EC50 = 3.16 µM).{65024} It inhibits VEGF-induced migration and capillary tube formation of primary human choroidal endothelial cells when used at a concentration of 0.1 µM.{65025} ATN-161 (1 mg/kg) reduces tumor growth and metastasis in an MDA-MB-231 mouse xenograft model and infarct volume and edema in a mouse model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).{65023,65026}
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